Pesquisa sobre: DNA TOPOISOMERASES 
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Descritor Inglês:   DNA Topoisomerases 
Descritor Espanhol:   ADN-Topoisomerasas 
Descritor Português:   DNA Topoisomerases 
Sinônimos Inglês:   Topoisomerases, DNA  
Categoria:   D08.811.399.403
Definição Inglês:   Enzymes that regulate the topology of DNA by actions such as breaking, relaxing, passing, and rejoining strands of DNA in cells. These enzymes are important components of the DNA replication system. They are classified by their substrate specificities. DNA TOPOISOMERASE I enzymes act on a single strand of DNA. DNA TOPOISOMERASE II enzymes act on double strands of DNA. 
Combinados Inglês:   DNA Topoisomerases/antagonists & inhibitors use Topoisomerase Inhibitors
 
Nota Histórica Inglês:   2002 
Qualificadores Permitidos Inglês:  
AD administration & dosage AE adverse effects
AN analysis BI biosynthesis
BL blood CF cerebrospinal fluid
CS chemical synthesis CH chemistry
CL classification DF deficiency
DE drug effects EC economics
GE genetics HI history
IM immunology IP isolation & purification
ME metabolism PK pharmacokinetics
PD pharmacology PH physiology
PO poisoning RE radiation effects
ST standards SD supply & distribution
TU therapeutic use TO toxicity
UL ultrastructure UR urine
Número do Registro:   36083 
Identificador Único:   D026942 

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